Data Portal of stage spesific RMEGs for Multiple Myeloma based on:

Stage-specific gene pair ratios highlight genes and mechanisms related to presymptomatic and symptomatic Multiple Myeloma

Grigoris Georgiou^1*, George Minadakis¹, Nestoras Karathanasis¹, Kyriaki Savva¹, Efi Athieniti¹, Marilena M Bourdakou¹, George M Spyrou^1*
¹Bioinformatics Department, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, Cyprus, P.O.Box 23462, 1683 Nicosia, Cyprus

*Grigoris Georgiou: Tel: +357-22392624; grigorisg@cing.ac.cy
*George Spyrou: Tel: +357-22392852; georges@cing.ac.cy

Graphical Abstract

Datasets Used in This Study

Summary of samples per disease stage and dataset, distinguishing internal and external datasets.

Raw Expression Data

Each matrix displays expression values with ENTREZ_IDs as row names. Boxplots show the expression distribution per sample.

GSE6477

GSE47552

Differential Expression and Pathway Enrichment Analysis

Select Dataset:

Select Condition:

P-value Threshold:

Adj.p-value Threshold:

Results Table

EnrichR Pathway Analysis

Select Database:

EnrichR Table

EnrichR Plot

GSEA Pathway Analysis

Select Database:

GSEA Table

GSEA Plot

Analysis based on Ratios of MEG-related pairs of genes

A computational method to exploit the discrimination power of within-sample gene pair ratios

Select Stage 1:

Select Stage 2:

P-value Threshold:

Adj.pvalue Threshold:

Data Portal of stage spesific RMEGs for Multiple Myeloma based on:

Stage-specific gene pair ratios highlight genes and mechanisms related to presymptomatic and symptomatic Multiple Myeloma

Graphical Abstract

Datasets Used in This Study

Raw Expression Data

GSE6477

GSE47552

Differential Expression and Pathway Enrichment Analysis

Results Table

EnrichR Pathway Analysis

EnrichR Table

EnrichR Plot

GSEA Pathway Analysis

GSEA Table

GSEA Plot

Monotonically Expression Analysis

Filters

MEG Table

MEG Plot

Analysis based on Ratios of MEG-related pairs of genes

Significant Ratios Table

Distribution of Selected Ratio

Accuracy & AUC for Selected Ratio