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DOCUMENTATION
Integrating Gene Regulatory Networks - Drug Ontologies
Pick-up an example
Level 2 - DRUGBANK Suppress network for KRAS
Level 2 - DRUGBANK Suppress network for EGFR
Level 2 - DRUGBANK Suppress network for VEGFA
Level 2 - L1000 Suppress network for KRAS
Level 2 - CMAP Suppress network for KRAS
Level 2 - CREEDS Suppress network for KRAS
Level 2 - DRUGBANK Suppress network for IL-6
Level 2 - DRUGBANK Suppress network for IL1B
Level 2 - DRUGBANK Suppress network for IL6R
Level 3 - DRUGBANK Suppress network for ACE2
Level 3 - DRUGBANK Suppress network for TMPRSS2
Level 3 - DRUGBANK Suppress network for CTSL
Level 1 - CTD Suppress network for KRAS
Level 1 - CTD Suppress network for EGFR
Level 1 - CTD Suppress network for VEGFA
Select Drug Reference Network
info
Use Drugbank Drug Repository
Use Signor Drug Repository
Use Gene-Budger L1000 Repository
-->
Use Gene-Budger CREEDS Drug Repository
-->
Use Gene-Budger CMAP Repository
CHEMBL: European Molecular Biology Laboratory
Use Comparative Toxicogenomics Database (CTD)
Select Network Level
info
Level 1: First Neighbours
Level 2: Second Neighbours
Level 3: Third Neighbours
Level 4: Forth Neighbours
Level 5: Fifth Neighbours
Select Modulation Type
info
I want to suppress
I want to activate
Select the gene of interest
info
Go for it
Integrating diverse drug ontologies and conditional regulatory networks to optimize the modulation of a target gene's expression
