Receptor-Focused Interventions
Against Orthoflavivirus Neuroinvasion and Entry

we use Systems Bioinformatics approaches to develop next generation analysis tools for infectious diseases

The REFINE HOP-ON action is an extension of the REFINE project funded under the Horizon Europe Widening Participation and Strengthening the European Research Area programme. Through the inclusion of a widening country partner, namely the Bioinformatics Department at The Cyprus Institute of Neurology & Genetics (CING), the project enhances its capacity to analyse complex biological data, accelerate antiviral discovery, and support the development of innovative therapeutic strategies against mosquito-borne orthoflaviviruses. Spesifically, the REFINE HOP-ON action strengthens the REFINE project by expanding the consortium with additional expertise in bioinformatics, computational drug discovery, and high-performance computing.

Systems Bioinformatics Against Orthoflavivirus Neuroinvasion and Entry

we use Systems Bioinformatics approaches to develop next generation tools

The REFINE HOP-ON Consortium

Through the REFINE HOP-ON action, the Bioinformatics Department at The Cyprus Institute of Neurology & Genetics (CING) actively collaborates with partners of the REFINE Consortium, including: Erasmus MC, University of Helsinki, University of Padova, University of Bonn, University of Melbourne, and University of Queensland.

The mission of the Department is to function as a hub of excellence in the areas of applied bioinformatics to early diagnosis, effective prognosis and drug discovery contributing to the concepts of Preventive, Personalized, and Precision Medicine. This is accomplished through state-of-the-art bioinformatics research, advanced education in postgraduate level and a bundle of bioinformatics pipelines that are offered either as services or as resources for collaboration.

A suite of publicly available bioinformatics tools, databases, and analysis platforms developed by the Department can be accessed at bioinformatics.cing.ac.cy

High Processing Units

we use parallel processing environments to optimize data handling

REFINE Associated Tools

This section showcases a collection of tools developed within the REFINE HOP-ON project. Researchers can explore datasets, visualize molecular and network interactions, and monitor the progress of therapeutic development: all within a unified, integrative platform.

A virus-host exploration framework

An integrated platform to explore virus-host interactions associated diseases and implicated pathways

Go For It

Projecting Viruses to PPIs

a drug repurposing tool based on pathogen protein commonalities

Go For It

Knowledge-Base Atlas (under-construction)

A Knowledge-Base Atlas focused on Orthoflavivirus Neuroinvasion and Entry

Go For It

Receptor-Focused Interventions

we use Systems Bioinformatics approaches to identify candidate host interactions

About IGRENE

IGRENE is a suite of bioinformatics tools designed to integrate Gene Regulatory Networks (GRNs) across multiple biological ontologies using a criteria-driven computational framework. The framework has been designed and optimized to support analytics in the context of the REFINE HOP-ON project by enabling gene-centric analyses tailored to specific molecular profiles, facilitating the identification of targeted interventions based on individual regulatory network signatures. IGRENE can be accessed through https://bioinformatics.cing.ac.cy/igrene/. Some selected tools are listed below.

Investigate Drug Influence Networks

Investigate both the activation and suppression networks stemming from a candidate drug to a specific target gene

Go For It

Projecting Drug Ontologies to GRNs

Project candidate drugs through GRNs to evaluate their potential modulatory effects on a gene of interest

Go For It

Investigate Gene Influence Networks

Investigate both the activation and suppression networks stemming from a source gene to a specific target gene

Go For It

Building Advanced Bioinformatics Tools

we use cutting-edge computational methodologies to enable modern biological discovery

Department of Bioinformatics
 The Cyprus Institute of Neurology & Genetics (CING)

6 International Airport Ave. Ayios Dhometios, 2370 Nicosia

Call us

+357 22392624

+ 357 22392852

Email us

bioinformatics@cing.ac.cy

Promoting Networking

focusing on new cross collaborations and new research ideas